Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21470911 | 0.85 | ESR2 (0.56) | ESR2NR1H2MAP3K5MEN1KMT2A | |
| SCHEMBL30260152 | 0.82 | ESR2 (0.64) | ESR2NR1H2MAP3K5MAPK1HDAC1 | |
| SCHEMBL21470912 | 0.82 | ESR2 (0.64) | ESR2NR1H2MAP3K5MAPK1HDAC1 | |
| SCHEMBL23684302 | 0.82 | ESR2 (0.64) | ESR2NR1H2MAP3K5MAPK1HDAC1 | |
| SCHEMBL30199587 | 0.82 | ESR2 (0.64) | ESR2NR1H2MAP3K5MAPK1HDAC1 | |
| SCHEMBL20330433 | 0.81 | ESR2 (0.60) | ESR2NR1H2MAP3K5MAPK1HDAC1 | |
| SCHEMBL30935164 | 0.81 | ESR2 (0.60) | ESR2NR1H2MAP3K5MAPK1HDAC1 | |
| SCHEMBL17065001 | 0.81 | NR1H2 (0.65) | ESR2NR1H2MAP3K5MAPK1HDAC1 | |
| SCHEMBL4171400 | 0.81 | NR1H2 (0.65) | ESR2NR1H2MAP3K5MAPK1HDAC1 | |
| SCHEMBL31067606 | 0.81 | NR1H2 (0.65) | ESR2NR1H2MAP3K5MAPK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194773-A1 | BICYCLIC HETEROCYCLIC AMIDE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194773-A1 | BICYCLIC HETEROCYCLIC AMIDE DERIVATIVE | NR0B1, NR2E1, NR0B2 | ESR2 620/4885NR1H2 313/4885MAP3K5 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.