Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.36 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2622288 | 0.86 | GABBR2 (0.47) | KMT2AGABBR2GABBR1MEN1CYP1A2 | |
| SCHEMBL4713140 | 0.85 | GABBR2 (0.46) | KMT2AGABBR2GABBR1MEN1CYP1A2 | |
| SCHEMBL4711841 | 0.85 | GABBR2 (0.46) | KMT2AGABBR2GABBR1MEN1CYP1A2 | |
| SCHEMBL22860693 | 0.84 | MERTK (0.46) | KMT2AGABBR2GABBR1MEN1CYP1A2 | |
| SCHEMBL4715006 | 0.81 | MERTK (0.50) | KMT2AGABBR2GABBR1MEN1CYP1A2 | |
| SCHEMBL20365996 | 0.80 | NR2F2 (0.45) | KMT2AMEN1KDM4EAXLMERTK | |
| SCHEMBL6424706 | 0.79 | KMT2A (0.60) | KMT2AMEN1CYP1A2KDM4EHSD17B10 | |
| SCHEMBL22184593 | 0.77 | KMT2A (0.51) | KMT2AGABBR2GABBR1MEN1CYP1A2 | |
| SCHEMBL6944320 | 0.76 | KMT2A (0.45) | KMT2AGABBR2GABBR1MEN1CYP1A2 | |
| SCHEMBL29507825 | 0.76 | MERTK (0.46) | KMT2AGABBR2GABBR1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3718560-A2 | CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE | The University of North Carolina at Chapel Hill (US) | 2020-10-07 | — | — | EP | disclosed |
| EP-3406260-B1 | CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2020-09-23 | — | — | EP | disclosed |
| EP-3025724-B1 | CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2018-07-11 | — | — | EP | disclosed |