Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL20366119 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL631100 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL631099 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL5391720 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL5427117 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL20366115 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL714313 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL711844 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL20560637 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL11560709 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10821093-B2 | Antibacterial microelement chelates and the use thereof in animal feeds | DR. BATA ZRT. (HU) | 2020-11-03 | — | — | US | disclosed |
| US-20180333384-A1 | ANTIBACTERIAL MICROELEMENT CHELATES AND THE USE THEREOF IN ANIMAL FEEDS | DR BATA ZRT (HU) | 2018-11-22 | — | — | US | disclosed |
| US-10022350-B2 | Antibacterial microelement chelates and the use thereof in animal feeds | DR. BATA ZRT. (HU) | 2018-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180333384-A1 | ANTIBACTERIAL MICROELEMENT CHELATES AND THE USE THEREOF IN ANIMAL FEEDS | SLC39A14, SLC39A3, CAT | SMN1; SMN2 2943/4885TDP1 4420/4885SLC22A6 2073/4885 |
| US-10022350-B2 | Antibacterial microelement chelates and the use thereof in animal feeds | SLC39A14, SLC39A3, CAT | SMN1; SMN2 3086/4885TDP1 4520/4885SLC22A6 2218/4885 |
| US-10821093-B2 | Antibacterial microelement chelates and the use thereof in animal feeds | SLC39A14, SLC39A3, CAT | SMN1; SMN2 3086/4885TDP1 4520/4885SLC22A6 2218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.