Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL20366119 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL631099 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL20366118 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL5391720 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL5427117 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL20366115 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL714313 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL711844 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL20560637 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 | |
| Malic Acid SCHEMBL11560709 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2TDP1SLC22A6TET2TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 945 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117796520-B | Acrylamide inhibitor, application thereof and method for reducing acrylamide in food | 湖南省产商品质量检验研究院 | 2026-05-19 | — | — | CN | claimed |
| EP-3519449-B1 | METHODS OF PREPARING A CATALYST | CHEVRON PHILLIPS CHEMICAL CO LP (US) | 2026-04-08 | — | — | EP | claimed |
| EP-4065236-B1 | METHOD FOR THE DECOLORIZATION OF KERATIN MATERIAL THAT HAS BEEN DYED USING A PIGMENT | HENKEL AG & CO KGAA (DE) | 2025-06-11 | — | — | EP | claimed |
| US-12312241-B1 | Zinc-vanadium catalyst for hydrogen generation | IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) | 2025-05-27 | — | — | US | claimed |
| WO-2025097045-A1 | COLLOIDAL FOOD BASE COMPOSITIONS COMPRISING MYCELIAL BIOMASS | THE FYNDER GROUP, INC (US) | 2025-05-08 | — | — | WO | claimed |
| WO-2025084804-A1 | STABILIZED FORMULATION OF AFFIMER AND METHOD FOR PREPARING SAME | 주식회사 엘지화학 | 2025-04-24 | — | — | WO | claimed |
| CN-119818484-A | 14-Amino acid and glucose composition stored in double-chamber bag and preparation method thereof | 湖北一半天制药有限公司 | 2025-04-15 | — | — | CN | claimed |
| CN-116143129-B | Preparation method and application of peanut-shaped ultra-high-purity silica sol | 万华化学集团股份有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119569608-A | Preparation method of iminodiacetonitrile IDAN | 万华化学集团股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| CN-119570870-A | Method for synthesizing L-2-aminobutyric acid and L-2-aminobutanamide hydrochloride and application | 浙江永太科技股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| US-5723081-A | Dispersion spinning process for polytetrafluoroethylene and related polymers | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-03-03 | — | — | US | claimed |
| EP-0668432-A2 | Process for treating oil-bearing formation | PHILLIPS PETROLEUM COMPANY (US) | 1995-08-23 | — | — | EP | claimed |
| US-5423380-A | Adding crosslinking agent intermittently to stream of aqueous solution of gellable polymer injected into subterranean formation | PHILLIPS PETROLEUM COMPANY (US) | 1995-06-13 | — | — | US | claimed |
| US-5094993-A | Catalyst support | TONEN CORPORATION (JP) | 1992-03-10 | — | — | US | claimed |
| EP-0237620-B1 | PROCESS FOR THE PREPARATION OF ORGANIC ACIDS | HÜLS AKTIENGESELLSCHAFT (DE) | 1990-08-22 | — | — | EP | claimed |
| US-4828993-A | ELECTRODIALYSIS | HULS AKTIENGESELLSCHAFT (DE) | 1989-05-09 | — | — | US | claimed |
| US-4506684-A | PRECIPITATION OF METAL SALTS | PHILIP MORRIS INCORPORATED (US) | 1985-03-26 | — | — | US | claimed |
| US-4232046-A | Liquid starch-urea ruminant feed and method of preparing same | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1980-11-04 | — | — | US | claimed |
| US-3988483-A | Liquid starch-urea ruminant feed and method of producing same | THE KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1976-10-26 | — | — | US | claimed |
| US-3956236-A | NYLON, POLYESTERS, OR POLYURETHANES | ALLIED CHEMICAL CORPORATION (US) | 1976-05-11 | — | — | US | claimed |