Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20004232 | 0.88 | ALK (0.69) | ALKGAKACOX3NR1I2ABCB11 | |
| SCHEMBL25447228 | 0.81 | ALK (0.80) | ALKGAKACOX3NR1I2ABCB11 | |
| SCHEMBL24676643 | 0.80 | ALK (0.59) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL24676735 | 0.80 | ALK (0.58) | ALK | |
| SCHEMBL897383 | 0.74 | ALK (0.72) | ALKGAKACOX3NR1I2ABCB11 | |
| SCHEMBL24676292 | 0.73 | ALK (0.64) | ALKGAKACOX3NR1I2ABCB11 | |
| SCHEMBL10272635 | 0.73 | ALK (0.67) | ALKGAKACOX3NR1I2ABCB11 | |
| SCHEMBL20366524 | 0.72 | ALK (0.74) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL21443133 | 0.72 | ALK (0.51) | ALK | |
| SCHEMBL20366345 | 0.72 | ALK (0.51) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613729-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |