Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20370154 | 0.88 | LMNA (0.42) | EGFRALOX5PTGS1NPC1RAB9A | |
| SCHEMBL6125174 | 0.87 | PPARG (0.41) | EGFRALOX5PTGS1PTGS2L3MBTL1 | |
| SCHEMBL6125183 | 0.86 | CA9 (0.44) | EGFRALOX5PTGS1PTGS2MAOB | |
| SCHEMBL6128414 | 0.85 | MAPT (0.41) | NPC1SMN1; SMN2KMT2A | |
| SCHEMBL6125173 | 0.84 | EGFR (0.40) | EGFRALOX5PTGS1PTGS2L3MBTL1 | |
| SCHEMBL19840907 | 0.75 | MCHR1 (0.33) | EGFRALOX5PTGS1PTGS2MCHR1 | |
| SCHEMBL19035744 | 0.75 | LMNA (0.45) | EGFRPTGS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17409114 | 0.73 | PPARG (0.44) | L3MBTL1KMT2AMEN1MAOBPPARG | |
| SCHEMBL19167952 | 0.72 | CA9 (0.47) | SMN1; SMN2L3MBTL1MAOB | |
| SCHEMBL17409115 | 0.70 | HTR2A (0.39) | NPC1RAB9ASMN1; SMN2L3MBTL1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424834-B1 | SYNTHESIS OF TETRACYCLINES AND INTERMEDIATES THEREOF | HARVARD COLLEGE (US) | 2018-07-11 | — | — | EP | disclosed |
| US-9688644-B2 | Synthesis of Tetracyclines and intermediates thereto | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-06-27 | — | — | US | disclosed |