Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259283 | 0.77 | PDE10A (0.48) | PDE10AADORA2AADORA1 | |
| SCHEMBL12641898 | 0.76 | RAB9A (0.46) | PDE10A | |
| SCHEMBL31326500 | 0.74 | PTGS1 (0.42) | PDE10AARADORA2AADORA3ADORA1 | |
| SCHEMBL12641920 | 0.74 | TLR8 (0.43) | PDE10AADORA2AADORA3ADORA1HRH4 | |
| SCHEMBL2039989 | 0.72 | PDE10A (0.52) | PDE10A | |
| SCHEMBL6902589 | 0.72 | PDE10A (0.52) | PDE10AADORA2AADORA3ADORA2BERN1 | |
| SCHEMBL7512631 | 0.72 | PDE10A (0.45) | PDE10A | |
| SCHEMBL2042236 | 0.72 | PDE10A (0.54) | PDE10A | |
| SCHEMBL14122433 | 0.70 | PDE10A (1.00) | PDE10A | |
| SCHEMBL2038582 | 0.70 | PDE10A (1.00) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9669029-B2 | Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2017-06-06 | — | — | US | disclosed |
| US-20150290191-A1 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2015-10-15 | — | — | US | disclosed |
| CN-102741250-B | As the heteroaromatic phenylimidazole derivatives of PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2015-10-14 | — | — | CN | disclosed |
| US-9096589-B2 | Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2015-08-04 | — | — | US | disclosed |
| EP-2513107-B1 | HETEROAROMATIC PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | LUNDBECK & CO AS H (DK) | 2014-07-30 | — | — | EP | disclosed |
| US-20120309714-A1 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2012-12-06 | — | — | US | disclosed |
| EP-2513107-A1 | HETEROAROMATIC PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | disclosed |
| CN-102741250-A | Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors | LUNDBECK & CO AS H | 2012-10-17 | — | — | CN | disclosed |
| WO-2011072694-A1 | HETEROAROMATIC PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309714-A1 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors | PDE10A, PDE3B, PDE4A | PDE10A 1/4885AR 1785/4885ADORA2A 188/4885 |
| US-20150290191-A1 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors | PDE10A, PDE3B, PDE12 | PDE10A 1/4885AR 1736/4885ADORA2A 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.