SCHEMBL2037162

SCHEMBL2037162

COc1cc2c(cc1OC)C(c1ccc(N)cc1)=NNC(=S)C2

nearest known ligand 0.74

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.74
CYP3A4 P08684 1/20 0.74
CYP2C9 P11712 1/20 0.74
MAPK1 P28482 1/20 0.74
CYP2C19 P33261 1/20 0.74
CHEK1 O14757 5/20 0.50
GRIA2 P42262 1/20 0.46
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA7 P43166 1/20 0.40
CA9 Q16790 1/20 0.40
CA14 Q9ULX7 1/20 0.40
SLC2A1 P11166 1/20 0.39
PKM P14618 1/20 0.38
RAD52 P43351 1/20 0.38
MAPK10 P53779 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1056361 0.85 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL29651353 0.85 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7607880 0.76 CYP1A2 (0.83) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
Nerisopam SCHEMBL1004757 0.75 CYP1A2 (0.63) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
Nerisopam SCHEMBL8349837 0.75 CYP1A2 (0.63) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7234076 0.75 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7228807 0.74 MAPK1 (0.45) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL2054177 0.74 CYP1A2 (0.59) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7227773 0.73 MAPT (0.47) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7407689 0.73 CYP1A2 (0.80) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011076946-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALZHEIMER Universidad Del País Vasco (ES) 2011-06-30 WO claimed
WO-2011076946-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALZHEIMER Universidad Del País Vasco (ES) 2011-06-30 WO disclosed