Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12856249 | 0.88 | MEN1 (0.72) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL13559793 | 0.86 | SIGMAR1 (0.65) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL13284339 | 0.86 | MEN1 (0.79) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL27882880 | 0.85 | KDM4E (0.60) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL3161038 | 0.84 | MEN1 (0.82) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL27448022 | 0.84 | KDM4E (0.56) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL9096094 | 0.82 | SIGMAR1 (0.64) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL9094866 | 0.82 | SIGMAR1 (0.64) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL18704979 | 0.82 | MEN1 (0.57) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL28126563 | 0.82 | SIGMAR1 (0.64) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023570-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2018-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023570-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | KMT2A 1448/4885MEN1 1015/4885KDM4E 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.