Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18390106 | 0.83 | CYP1A2 (0.37) | CYP1A2CYP2C9CYP2D6CYP2C19CETP | |
| SCHEMBL20328008 | 0.82 | CYP1A2 (0.34) | CYP1A2CYP2C9CYP2D6CYP2C19CETP | |
| SCHEMBL18409206 | 0.82 | FFAR3 (0.48) | CYP1A2CYP2C9CETPALDH1A1MME | |
| SCHEMBL20148015 | 0.81 | MMP9 (0.36) | CYP1A2CYP2C9CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL19000021 | 0.80 | FFAR3 (0.40) | CYP1A2CYP2C9CETPALDH1A1MME | |
| SCHEMBL20328853 | 0.77 | MME (0.41) | CYP1A2CYP2C9CYP2D6CYP2C19CETP | |
| SCHEMBL25221272 | 0.73 | CYP1A2 (0.49) | CYP1A2CETPALDH1A1MMEFFAR3 | |
| SCHEMBL25223577 | 0.73 | TSHR (0.48) | CYP1A2CYP2C9CYP2D6ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL25218542 | 0.72 | CYP1A2 (0.47) | CYP1A2CETPALDH1A1MMEFFAR3 | |
| SCHEMBL20353554 | 0.71 | FFAR3 (0.36) | FFAR3MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023570-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2018-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023570-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | CYP1A2 3702/4885CYP2C9 3533/4885CYP2D6 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.