Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099617 | 0.83 | PARP10 (0.62) | HTTPARP10ALDH1A1THRBKMT2A | |
| SCHEMBL8574831 | 0.81 | PARP10 (0.62) | PARP10ALDH1A1KMT2AGLAMAPT | |
| SCHEMBL28569539 | 0.80 | ALDH1A1 (0.51) | HTTPARP10ALDH1A1KMT2AMAPT | |
| SCHEMBL19043416 | 0.80 | PARP10 (0.62) | HTTPARP10ALDH1A1THRBKMT2A | |
| SCHEMBL17937297 | 0.79 | PARP10 (0.60) | HTTPARP10ALDH1A1THRBKMT2A | |
| SCHEMBL30628298 | 0.77 | ALDH1A1 (0.59) | HTTPARP10ALDH1A1KMT2AGLA | |
| SCHEMBL17420537 | 0.77 | ALDH1A1 (0.59) | HTTPARP10ALDH1A1KMT2AGLA | |
| SCHEMBL5121870 | 0.76 | ALDH1A1 (0.73) | HTTPARP10ALDH1A1KMT2AMAPT | |
| SCHEMBL23328816 | 0.74 | ALDH1A1 (0.56) | HTTPARP10ALDH1A1KMT2AGLA | |
| SCHEMBL23328225 | 0.73 | ALDH1A1 (0.50) | HTTPARP10ALDH1A1KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594563-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-07-18 | — | — | EP | disclosed |