Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17226375 | 0.98 | SMN1; SMN2 (0.55) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL28664096 | 0.83 | EPHX1 (0.59) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL12457773 | 0.79 | EPHX1 (0.53) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL3075216 | 0.78 | EPHX1 (0.68) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7302572 | 0.77 | EPHX1 (0.61) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL8394299 | 0.77 | EPHX1 (0.61) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL10587847 | 0.76 | ALDH1A1 (0.83) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL24826264 | 0.74 | EPHX1 (0.49) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL2096409 | 0.74 | EPHX1 (0.63) | EPHX1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL879434 | 0.74 | EPHX1 (0.63) | EPHX1HPGDKMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594563-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-07-18 | — | — | EP | disclosed |