Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20385128 | 0.88 | HTT (0.41) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20385142 | 0.87 | HTT (0.40) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20385141 | 0.86 | KCNN4 (0.40) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20385152 | 0.85 | HTT (0.47) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20385135 | 0.81 | NPC1 (0.44) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20385115 | 0.81 | HTT (0.43) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20385154 | 0.80 | HTT (0.43) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16919552 | 0.80 | HTT (0.47) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20385161 | 0.80 | HTT (0.43) | HTTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20385121 | 0.80 | HTT (0.43) | HTTPOLBRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867215-B1 | TETRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | SANIONA AS (DK) | 2018-07-18 | — | — | EP | disclosed |