Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521937 | 0.73 | PDE3B (0.52) | PDE3BPDE3AALDH1A1KDM4EGLA | |
| SCHEMBL1239192 | 0.71 | PDE3B (0.56) | PDE3BPDE3AALDH1A1MAOAMAOB | |
| SCHEMBL30094448 | 0.68 | PDE3B (0.68) | PDE3BPDE3AALDH1A1MAOAMAOB | |
| SCHEMBL153506 | 0.66 | EIF2AK2 (0.74) | PDE3BPDE3AALDH1A1MAOAMAOB | |
| SCHEMBL31040124 | 0.66 | PDE3B (0.66) | PDE3BPDE3AALDH1A1MAOAMAOB | |
| SCHEMBL20214 | 0.66 | PDE3B (0.66) | PDE3BPDE3AALDH1A1MAOAMAOB | |
| SCHEMBL18329254 | 0.66 | PDE3B (0.50) | PDE3BPDE3AALDH1A1MAOAMAOB | |
| SCHEMBL18329221 | 0.65 | PDE3B (0.46) | PDE3BPDE3AALDH1A1KDM4EGLA | |
| SCHEMBL24221517 | 0.65 | ALDH1A1 (0.43) | PDE3BPDE3AALDH1A1KDM4EHPGD | |
| SCHEMBL18329219 | 0.64 | PDE3B (0.45) | PDE3BPDE3AALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083569-B1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | AGENEBIO INC (US) | 2022-01-26 | — | — | EP | disclosed |
| WO-2018130869-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | AGENEBIO, INC. (US) | 2018-07-19 | — | — | WO | disclosed |
| WO-2018130868-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | AGENEBIO, INC. (US) | 2018-07-19 | — | — | WO | disclosed |