Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.36 |
| ▸ | CA2 | P00918 | 6/20 | 0.36 |
| ▸ | CA9 | Q16790 | 5/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12035557 | 0.87 | CA1 (0.40) | CA1CA2CA9CA12MAPT | |
| SCHEMBL2306972 | 0.85 | CA1 (0.39) | CA1CA2CA9CA12MAPT | |
| SCHEMBL1474319 | 0.81 | CA1 (0.36) | CA1CA2CA9CA12MAPT | |
| SCHEMBL30782701 | 0.81 | ALDH1A1 (0.47) | CA1CA2CA9CA12MAPT | |
| SCHEMBL18272435 | 0.81 | ALDH1A1 (0.47) | CA1CA2CA9CA12MAPT | |
| SCHEMBL18272393 | 0.81 | ALDH1A1 (0.47) | CA1CA2CA9CA12MAPT | |
| SCHEMBL18272434 | 0.81 | ALDH1A1 (0.47) | CA1CA2CA9CA12MAPT | |
| SCHEMBL18272436 | 0.81 | ALDH1A1 (0.47) | CA1CA2CA9CA12MAPT | |
| SCHEMBL28404770 | 0.81 | ALDH1A1 (0.47) | CA1CA2CA9CA12MAPT | |
| SCHEMBL18272445 | 0.81 | ALDH1A1 (0.47) | CA1CA2CA9CA12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108329311-B | Tricyclic compound as selective estrogen receptor down-regulator and application thereof | 南京圣和药业股份有限公司 | 2022-02-22 | — | — | CN | disclosed |
| WO-2018130124-A1 | TRICYCLIC COMPOUND AS SELECTIVE ESTROGEN RECEPTOR DOWN-REGULATOR AND USE THEREOF | 南京圣和药业股份有限公司 | 2018-07-19 | — | — | WO | disclosed |