Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 2/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13153124 | 0.80 | KMT2A (0.46) | L3MBTL1PLK4PAK4HTR2CHTR2A | |
| SCHEMBL29882851 | 0.77 | PLK4 (0.48) | L3MBTL1PLK4PAK4HTR2CHTR2A | |
| SCHEMBL20389659 | 0.77 | PLK4 (0.48) | L3MBTL1PLK4PAK4HTR2CHTR2A | |
| SCHEMBL18012909 | 0.77 | BACE1 (0.43) | L3MBTL1PLK4PAK4HTR2CHTR2A | |
| SCHEMBL14769543 | 0.75 | GRK2 (0.40) | GRK2ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL19966396 | 0.73 | FGFR1 (0.39) | FGFR1L3MBTL1PLK4PAK4GRK2 | |
| SCHEMBL16244570 | 0.73 | AXL (0.41) | — | |
| SCHEMBL12684216 | 0.73 | GRK2 (0.41) | PAK4GRK2 | |
| SCHEMBL14767819 | 0.73 | TSHR (0.49) | L3MBTL1GRK2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL29904820 | 0.72 | ALDH1A1 (0.51) | L3MBTL1GAAALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3007694-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF BLADDER CANCER | SANOFI SA (FR) | 2018-07-18 | — | — | EP | disclosed |