Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.51 |
| ▸ | CA2 | P00918 | 10/20 | 0.51 |
| ▸ | CA9 | Q16790 | 9/20 | 0.51 |
| ▸ | CA12 | O43570 | 8/20 | 0.51 |
| ▸ | CA7 | P43166 | 4/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.51 |
| ▸ | CA5A | P35218 | 3/20 | 0.51 |
| ▸ | CA4 | P22748 | 3/20 | 0.51 |
| ▸ | CA6 | P23280 | 3/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.51 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18361724 | 0.99 | CA12 (0.52) | CA1CA2CA9CA12CA7 | |
| SCHEMBL18361705 | 0.73 | CA1 (0.74) | CA1CA2CA9CA12CA7 | |
| SCHEMBL18361704 | 0.73 | CA1 (0.60) | CA1CA2CA9CA12CA7 | |
| SCHEMBL8413926 | 0.73 | KHK (0.45) | — | |
| SCHEMBL28543449 | 0.73 | DPP4 (0.60) | CA1CA2CA9CA12CA7 | |
| SCHEMBL14549757 | 0.73 | DPP4 (0.60) | CA1CA2CA9CA12CA7 | |
| SCHEMBL18361665 | 0.72 | CA1 (0.48) | CA1CA2CA9CA12CA7 | |
| SCHEMBL18361587 | 0.71 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL31662436 | 0.71 | F10 (0.43) | TDP1 | |
| SCHEMBL18361706 | 0.70 | CA2 (0.58) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922345-B | Arylsulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use | 圣诺康生命科学公司 | 2021-03-23 | — | — | CN | claimed |
| CN-107922345-B | Arylsulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use | 圣诺康生命科学公司 | 2021-03-23 | — | — | CN | disclosed |
| US-10562859-B2 | Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use | SIGNALCHEM LIFESCIENCES CORPORATION (CA) | 2020-02-18 | — | — | US | disclosed |
| US-20180201584-A1 | ARYL SULFONAMIDE COMPOUNDS AS CARBONIC ANHYDRASE INHIBITORS AND THEIR THERAPEUTIC USE | SIGNALCHEM LIFESCIENCES CORPORATION (CA) | 2018-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10562859-B2 | Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use | CA9, CA4, CA7 | CA1 8/4885CA2 5/4885CA9 1/4885 |
| US-20180201584-A1 | ARYL SULFONAMIDE COMPOUNDS AS CARBONIC ANHYDRASE INHIBITORS AND THEIR THERAPEUTIC USE | CA9, CA4, CA7 | CA1 8/4885CA2 5/4885CA9 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.