Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20388025 | 0.79 | ALDH1A1 (0.81) | ALDH1A1SMN1; SMN2LMNAHSD17B10CNR1 | |
| SCHEMBL2336091 | 0.78 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2LMNAHSD17B10CNR1 | |
| SCHEMBL20393935 | 0.77 | MEN1 (0.69) | ALDH1A1LMNACNR1CNR2MEN1 | |
| SCHEMBL13979925 | 0.74 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2LMNACNR1CNR2 | |
| SCHEMBL18112914 | 0.72 | MAPT (0.63) | ALDH1A1SMN1; SMN2LMNAHTTTSHR | |
| SCHEMBL20393941 | 0.72 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2LMNAHTTCRHBP | |
| SCHEMBL20404463 | 0.72 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2LMNAHTTCRHBP | |
| SCHEMBL12188831 | 0.71 | HTR2A (0.72) | ALDH1A1SMN1; SMN2LMNAHSD17B10HTT | |
| SCHEMBL11685215 | 0.70 | ALDH1A1 (0.53) | ALDH1A1TDP1MEN1KMT2AKDM4E | |
| SCHEMBL400238 | 0.70 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2LMNAHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913710-B2 | Benzene disulfonamide for the treatment of cancer | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V (DE) | 2021-02-09 | — | — | US | disclosed |
| US-10913710-B2 | Benzene disulfonamide for the treatment of cancer | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V (DE) | 2021-02-09 | — | — | US | disclosed |
| EP-3351544-A1 | BENZENE DISULFONAMIDE FOR THE TREATMENT OF CANCER | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2018-07-25 | — | — | EP | disclosed |
| EP-3351544-A1 | BENZENE DISULFONAMIDE FOR THE TREATMENT OF CANCER | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2018-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913710-B2 | Benzene disulfonamide for the treatment of cancer | DUSP6, DUSP26, RASSF2 | ALDH1A1 637/4885SMN1; SMN2 4153/4885LMNA 3515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.