Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 7/20 | 0.76 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2426895 | 0.89 | MGLL (0.62) | MGLLFFAR4TRPM8TRPV1EPHX2 | |
| SCHEMBL3346329 | 0.88 | MGLL (0.60) | MGLLFFAR4 | |
| SCHEMBL3350789 | 0.88 | MGLL (0.60) | MGLLFFAR4 | |
| SCHEMBL3350785 | 0.88 | MGLL (0.60) | MGLLFFAR4 | |
| SCHEMBL2429904 | 0.87 | MGLL (0.75) | MGLLFFAR4 | |
| SCHEMBL20397181 | 0.86 | MGLL (1.00) | MGLLFFAR4 | |
| SCHEMBL20397302 | 0.86 | MGLL (1.00) | MGLLFFAR4 | |
| SCHEMBL2435729 | 0.84 | MGLL (0.55) | MGLL | |
| SCHEMBL2435728 | 0.84 | MGLL (0.55) | MGLL | |
| SCHEMBL23859715 | 0.84 | MGLL (0.63) | MGLLFFAR4NOTUMEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328849-B9 | 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS | PFIZER (US) | 2021-01-06 | — | — | EP | claimed |
| EP-3328849-B1 | 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS | PFIZER (US) | 2020-09-09 | — | — | EP | claimed |
| WO-2018134698-A1 | HETEROCYCLIC SPIRO COMPOUNDS AS MAGL INHIBITORS | PFIZER INC. (US) | 2018-07-26 | — | — | WO | disclosed |