Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | GAK | O14976 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20421780 | 0.79 | RET (0.42) | TTKRET | |
| Hydrochloric Acid SCHEMBL3849804 | 0.67 | FLT3 (0.37) | — | |
| SCHEMBL1570421 | 0.60 | — | — | |
| SCHEMBL20409406 | 0.58 | EGLN2 (0.46) | TTKEGLN2 | |
| SCHEMBL20409604 | 0.58 | EGLN2 (0.46) | KDM4EALDH1A1TTKEGLN2RET | |
| Hydrochloric Acid SCHEMBL3847228 | 0.57 | ALDH1A1 (0.42) | KDM4EALDH1A1 | |
| SCHEMBL2419516 | 0.57 | MEN1 (0.40) | — | |
| Hydrochloric Acid SCHEMBL3847203 | 0.56 | KCNH2 (0.46) | — | |
| SCHEMBL13149485 | 0.55 | HRH3 (0.51) | KDM4EALDH1A1GPR119EGLN2 | |
| SCHEMBL18613260 | 0.55 | FYN (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558991-A2 | COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR | Plexxikon Inc. (US) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018136202-A2 | COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2018-07-26 | — | — | WO | disclosed |