Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | PAK4 | O96013 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | PRKX | P51817 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MELK | Q14680 | 2/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27029429 | 0.87 | ADORA2A (0.43) | ADORA2AADORA2BADORA1KLKB1CDC7 | |
| SCHEMBL30402235 | 0.87 | ADORA2A (0.38) | ADORA2AADORA2BADORA1KLKB1CDC7 | |
| SCHEMBL20401495 | 0.87 | ADORA2A (0.38) | ADORA2AADORA2BADORA1KLKB1CDC7 | |
| SCHEMBL20436680 | 0.86 | CDC7 (0.39) | ADORA2AADORA2BADORA1KLKB1CDC7 | |
| SCHEMBL20416991 | 0.85 | ADORA2B (0.43) | ADORA2AADORA2BADORA1KLKB1CLK4 | |
| SCHEMBL20436681 | 0.85 | CDC7 (0.40) | ADORA2AADORA2BADORA1KLKB1CDC7 | |
| SCHEMBL20436658 | 0.85 | ADORA2A (0.40) | ADORA2AADORA2BADORA1KLKB1CDC7 | |
| SCHEMBL20436661 | 0.83 | KDM4E (0.41) | ADORA2AADORA2BADORA1KLKB1CDC7 | |
| SCHEMBL30401511 | 0.83 | ADORA2A (0.49) | ADORA2AADORA2BADORA1 | |
| SCHEMBL20400627 | 0.83 | ADORA2A (0.49) | ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136700-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. (US) | 2018-07-26 | — | — | WO | disclosed |