Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20403447 | 0.80 | GRIN2A (0.35) | GRIN1GRIN2AGRIA2MAPTRXFP1 | |
| SCHEMBL16645547 | 0.64 | GRIN2A (0.69) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL20403425 | 0.62 | GRIN2A (0.58) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645601 | 0.57 | GRIN2A (0.51) | GRIN1GRIN2AGRIA2MAPTRXFP1 | |
| SCHEMBL16645604 | 0.57 | GRIN2A (0.60) | GRIN1GRIN2AGRIA2MAPTRXFP1 | |
| SCHEMBL20403426 | 0.57 | GRIN1 (0.49) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL20403382 | 0.56 | GRIN1 (0.50) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL17975719 | 0.56 | GRIN1 (0.56) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645974 | 0.55 | GRIN2A (0.50) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645648 | 0.55 | GRIN2A (0.59) | GRIN1GRIN2AGRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-B1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2018-07-25 | — | — | EP | disclosed |