Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 11/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 8/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20403441 | 0.80 | GRIN1 (0.37) | GRIN2AGRIN1GRIA2RXFP1MAPT | |
| SCHEMBL20403382 | 0.77 | GRIN1 (0.50) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645605 | 0.74 | GRIN2A (0.59) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL16645603 | 0.74 | GRIN2A (0.50) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL16645923 | 0.73 | GRIN2A (0.48) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL16645601 | 0.55 | GRIN2A (0.51) | GRIN2AGRIN1GRIA2RXFP1MAPT | |
| SCHEMBL16645604 | 0.55 | GRIN2A (0.60) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL17975719 | 0.55 | GRIN1 (0.56) | GRIN2AGRIN1GRIA2 | |
| SCHEMBL16645607 | 0.54 | GRIN2A (0.54) | GRIN2AGRIN1GRIA2GRIN2DGRIN2C | |
| SCHEMBL16638013 | 0.54 | GRIN1 (0.70) | GRIN2AGRIN1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-B1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2018-07-25 | — | — | EP | disclosed |