Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 8/20 | 0.42 |
| ▸ | HSPA5 | P11021 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | MGMT | P16455 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ATG7 | O95352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19292561 | 0.91 | PDE2A (0.35) | PDE2AHSPA5KDM4EALDH1A1GAA | |
| SCHEMBL18787315 | 0.88 | PDE2A (0.52) | PDE2AHSPA5 | |
| SCHEMBL13648874 | 0.86 | PDE2A (0.44) | PDE2AHSPA5 | |
| SCHEMBL23369100 | 0.83 | HSPA5 (0.39) | PDE2AHSPA5CDK1CCNB1MGMT | |
| SCHEMBL15257389 | 0.83 | HSP90AB1 (0.34) | KDM4E | |
| SCHEMBL18787314 | 0.80 | PDE2A (0.51) | PDE2AHSPA5 | |
| SCHEMBL24557986 | 0.79 | PDE2A (0.59) | PDE2AHSPA5 | |
| SCHEMBL18788249 | 0.79 | PDE2A (0.49) | PDE2AHSPA5 | |
| SCHEMBL20653964 | 0.79 | PDE2A (0.47) | PDE2AHSPA5 | |
| SCHEMBL18787318 | 0.78 | PDE2A (0.48) | PDE2AHSPA5ATG7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351552-A1 | 2'- SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | Gilead Sciences, Inc. (US) | 2018-07-25 | — | — | EP | disclosed |