Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | MGMT | P16455 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | ATG7 | O95352 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20404119 | 0.83 | PDE2A (0.42) | HSPA5PDE2ACDK1CCNB1MGMT | |
| SCHEMBL13648874 | 0.80 | PDE2A (0.44) | HSPA5PDE2ACA1CA2CA9 | |
| SCHEMBL18787315 | 0.77 | PDE2A (0.52) | HSPA5PDE2ACA1CA2CA9 | |
| SCHEMBL19292561 | 0.76 | PDE2A (0.35) | HSPA5PDE2ACDK1CCNB1MGMT | |
| SCHEMBL12253818 | 0.76 | PDE2A (0.37) | HSPA5PDE2ACDK1CCNB1MGMT | |
| SCHEMBL18787325 | 0.72 | PDE2A (0.38) | HSPA5PDE2ACDK1CCNB1MGMT | |
| SCHEMBL12836757 | 0.71 | PDE2A (0.38) | HSPA5PDE2AATG7 | |
| SCHEMBL19292106 | 0.71 | DNMT1 (0.44) | ADORA2A | |
| SCHEMBL19859840 | 0.71 | PDE2A (0.42) | HSPA5PDE2AATG7CA1CA2 | |
| SCHEMBL19292122 | 0.70 | TAAR1 (0.36) | HSPA5PDE2ATAAR1ATG7HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351552-B1 | 2'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES INC (US) | 2021-05-19 | — | — | EP | disclosed |