Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21028899 | 0.91 | PIK3CD (0.60) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1PIK3CG | |
| SCHEMBL358165 | 0.89 | PIK3CD (0.62) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1PIK3CG | |
| SCHEMBL20081323 | 0.88 | PIK3CD (0.51) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1PIK3CG | |
| SCHEMBL15817691 | 0.87 | PIK3CD (0.77) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1PIK3CG | |
| SCHEMBL16597182 | 0.86 | SMN1; SMN2 (0.50) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1PIK3CG | |
| SCHEMBL17235505 | 0.86 | ESR1 (0.60) | SMN1; SMN2ALDH1A1ESR1ESR2NPC1 | |
| SCHEMBL16597185 | 0.86 | PDE10A (0.52) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1PIK3CG | |
| SCHEMBL9604076 | 0.86 | PIK3CD (0.76) | PIK3CDPIK3R1ALDH1A1PIK3CGL3MBTL1 | |
| SCHEMBL22237904 | 0.85 | PIK3CD (0.50) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1PIK3CG | |
| SCHEMBL15864426 | 0.84 | PIK3CD (0.67) | PIK3CDPIK3R1PIK3CGNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935246-B1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2018-07-25 | — | — | EP | disclosed |