Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20404396 | 0.91 | PIK3CD (0.57) | PIK3CDUSP2PIK3R1SMN1; SMN2LMNA | |
| SCHEMBL15817691 | 0.88 | PIK3CD (0.77) | PIK3CDUSP2MEN1KMT2ACYP1A2 | |
| SCHEMBL16597165 | 0.87 | PIK3CD (0.79) | PIK3CDUSP2PIK3R1LMNAPIK3CG | |
| SCHEMBL15864426 | 0.86 | PIK3CD (0.67) | PIK3CDUSP2MEN1KMT2ACYP1A2 | |
| SCHEMBL20081364 | 0.86 | USP2 (0.56) | PIK3CDUSP2MEN1KMT2ACYP1A2 | |
| SCHEMBL16597160 | 0.86 | USP2 (0.56) | PIK3CDUSP2MEN1KMT2ACYP1A2 | |
| SCHEMBL16597180 | 0.86 | USP2 (0.56) | PIK3CDUSP2MEN1KMT2ACYP1A2 | |
| SCHEMBL358165 | 0.85 | PIK3CD (0.62) | PIK3CDMEN1KMT2APIK3R1SMN1; SMN2 | |
| SCHEMBL15818242 | 0.84 | PIK3CD (0.55) | PIK3CDMEN1KMT2APIK3R1SMN1; SMN2 | |
| SCHEMBL17235509 | 0.84 | USP2 (0.63) | USP2MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046563-B1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AS PI3-KINASE INHIBITORS | CALITOR SCIENCES LLC (US) | 2019-05-29 | — | — | EP | disclosed |