Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.44 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20406219 | 0.83 | PDE10A (0.46) | PDE10AALDH1A1MAPTATM | |
| SCHEMBL4008297 | 0.81 | PDE10A (0.45) | PDE10ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL31395515 | 0.79 | PDE10A (0.53) | PDE10ASMN1; SMN2DRD1KMT2A | |
| SCHEMBL20406196 | 0.79 | PDE10A (0.43) | PDE10AALDH1A1MAPTATMDRD1 | |
| SCHEMBL4008329 | 0.77 | PDE10A (0.51) | PDE10AALDH1A1MAPTDRD1TDP1 | |
| SCHEMBL20406262 | 0.77 | PDE10A (0.42) | PDE10AALDH1A1MAPTATMDRD1 | |
| SCHEMBL20406612 | 0.76 | PDE10A (0.48) | PDE10ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20406238 | 0.76 | PDE10A (0.48) | PDE10ARAB9AALDH1A1MAPTATM | |
| SCHEMBL20406610 | 0.76 | PDE10A (0.51) | PDE10ARAB9ADRD1TDP1MEN1 | |
| SCHEMBL7910614 | 0.76 | KMT2A (0.59) | PDE10ASMN1; SMN2ALDH1A1MAPTDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |