Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734395 | 0.91 | ALDH1A1 (0.72) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL733471 | 0.90 | HSD17B10 (0.61) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL734722 | 0.90 | ALDH1A1 (0.59) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL12264959 | 0.88 | ALDH1A1 (0.57) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL18415242 | 0.87 | SMN1; SMN2 (0.77) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL735258 | 0.85 | ALDH1A1 (0.67) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL18539559 | 0.85 | PIK3CG (0.61) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL735179 | 0.85 | HSD17B10 (0.64) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL27764793 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA | |
| SCHEMBL735038 | 0.82 | PIK3CG (0.75) | ALDH1A1HSD17B10RXFP1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180209956-A1 | HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180209956-A1 | HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies | RAD52, BRCA1, RAD50 | ALDH1A1 3621/4885HSD17B10 1846/4885RXFP1 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.