Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17980517 | 0.81 | NR3C1 (1.00) | NR3C1 | |
| SCHEMBL17981707 | 0.81 | KMT2A (0.44) | NR3C1ALDH1A1KDM4E | |
| SCHEMBL20413387 | 0.81 | NR3C1 (0.52) | NR3C1ALDH1A1 | |
| SCHEMBL20413369 | 0.80 | NR3C1 (0.72) | NR3C1 | |
| SCHEMBL20413377 | 0.79 | NR3C1 (0.73) | NR3C1 | |
| SCHEMBL20413399 | 0.78 | NR3C1 (0.73) | NR3C1 | |
| SCHEMBL17963208 | 0.77 | KDM4E (0.43) | NR3C1HPGDALDH1A1KDM4E | |
| SCHEMBL20413603 | 0.77 | NR3C1 (0.69) | NR3C1HPGDLMNAALDH1A1KDM4E | |
| SCHEMBL20413411 | 0.76 | NR3C1 (0.70) | NR3C1 | |
| SCHEMBL20413604 | 0.76 | NR3C1 (0.69) | NR3C1HPGDLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | Sanford Burnham Prebys Medical Discovery Institute | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | NR3C1, NR3C2, GRK3 | NR3C1 1/4885PTGS2 854/4885HPGD 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.