Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943334 | 0.83 | USP2 (0.47) | CTSKUSP2SMN1; SMN2HPGDEPHX2 | |
| SCHEMBL17830842 | 0.81 | USP2 (0.45) | CTSKUSP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL18674264 | 0.79 | USP2 (0.41) | CTSKUSP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL18314373 | 0.78 | USP2 (0.43) | USP2SMN1; SMN2HPGDJAK2JAK1 | |
| SCHEMBL16340560 | 0.78 | JAK2 (0.46) | CTSKMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL345355 | 0.78 | JAK2 (0.44) | CTSKUSP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL25630169 | 0.78 | USP2 (0.51) | USP2SMN1; SMN2HPGDEPHX2GPR119 | |
| SCHEMBL18674256 | 0.77 | USP2 (0.42) | CTSKUSP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL6914295 | 0.76 | USP2 (0.50) | USP2SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL10172533 | 0.76 | USP2 (0.50) | USP2SMN1; SMN2DPP4HPGDEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3571202-B1 | HETEROCYCLIC SPIRO COMPOUNDS AS MAGL INHIBITORS | PFIZER (US) | 2021-06-30 | — | — | EP | disclosed |
| WO-2018134698-A1 | HETEROCYCLIC SPIRO COMPOUNDS AS MAGL INHIBITORS | PFIZER INC. (US) | 2018-07-26 | — | — | WO | disclosed |