Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14617840 | 0.84 | HCAR2 (0.44) | HCAR2TTRCA12CA1CA2 | |
| SCHEMBL30037818 | 0.80 | HCAR2 (0.38) | HCAR2 | |
| SCHEMBL14693491 | 0.77 | HCAR2 (0.41) | HCAR2NPSR1L3MBTL1 | |
| SCHEMBL14693492 | 0.77 | HCAR2 (0.41) | HCAR2NPSR1L3MBTL1 | |
| SCHEMBL17426067 | 0.77 | ALDH1A1 (0.33) | MAPTALDH1A1CYP3A4POLB | |
| SCHEMBL20261888 | 0.76 | NPSR1 (0.42) | HCAR2LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL10181124 | 0.76 | NPSR1 (0.42) | HCAR2LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL11805646 | 0.76 | HCAR2 (0.52) | MAPTHCAR2ALDH1A1LMNATTR | |
| SCHEMBL18909623 | 0.76 | HTR2A (0.34) | POLB | |
| SCHEMBL7609837 | 0.76 | HCAR2 (0.52) | MAPTHCAR2ALDH1A1LMNATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793576-B2 | Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof | CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD. (CN) | 2020-10-06 | — | — | US | disclosed |
| US-10793576-B2 | Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof | CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD. (CN) | 2020-10-06 | — | — | US | disclosed |
| US-20190315758-A1 | COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD. (CN) | 2019-10-17 | — | — | US | disclosed |
| US-20190315758-A1 | COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD. (CN) | 2019-10-17 | — | — | US | disclosed |
| WO-2018133151-A1 | COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | 成都倍特药业有限公司 | 2018-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315758-A1 | COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | BTK, SYK, LYN | MAPT 4186/4885HCAR2 4552/4885ALDH1A1 4326/4885 |
| US-10793576-B2 | Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof | BTK, SYK, LYN | MAPT 4186/4885HCAR2 4552/4885ALDH1A1 4326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.