Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20436732 | 0.98 | HDAC2 (0.36) | CNR1HDAC2HDAC8HDAC6LRRK2 | |
| SCHEMBL20417003 | 0.92 | CCNA2 (0.36) | CNR1LRRK2PRKCQMAP4K1 | |
| SCHEMBL26217266 | 0.92 | CCNA2 (0.36) | CNR1LRRK2PRKCQMAP4K1 | |
| SCHEMBL20436733 | 0.90 | CCNA2 (0.36) | CNR1LRRK2PRKCQMAP4K1 | |
| SCHEMBL20436641 | 0.90 | CCNA2 (0.36) | CNR1LRRK2PRKCQMAP4K1 | |
| SCHEMBL20416673 | 0.88 | CNR1 (0.38) | CNR1HDAC2HDAC8HDAC6LRRK2 | |
| SCHEMBL20417139 | 0.88 | PDE4A (0.36) | HDAC2HDAC8HDAC6LRRK2MAPK14 | |
| SCHEMBL20436631 | 0.87 | ADORA2A (0.40) | HDAC2HDAC8HDAC6MAPK14ADORA2A | |
| SCHEMBL20416648 | 0.87 | ADORA2A (0.46) | LRRK2ADORA2AADORA2BADORA1 | |
| SCHEMBL20436640 | 0.86 | ADORA2A (0.37) | CNR1HDAC2HDAC8HDAC6LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4310082-A2 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | Arcus Biosciences, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2018136700-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. (US) | 2018-07-26 | — | — | WO | disclosed |