Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20417025 | 0.98 | CNR1 (0.38) | HDAC2HDAC8HDAC6LRRK2CNR1 | |
| SCHEMBL20436641 | 0.92 | CCNA2 (0.36) | LRRK2CNR1MAP4K1PRKCQ | |
| SCHEMBL20436733 | 0.92 | CCNA2 (0.36) | LRRK2CNR1MAP4K1PRKCQ | |
| SCHEMBL20417003 | 0.90 | CCNA2 (0.36) | LRRK2CNR1MAP4K1PRKCQ | |
| SCHEMBL26217266 | 0.90 | CCNA2 (0.36) | LRRK2CNR1MAP4K1PRKCQ | |
| SCHEMBL20436640 | 0.88 | ADORA2A (0.37) | HDAC2HDAC8HDAC6LRRK2CNR1 | |
| SCHEMBL20417139 | 0.88 | PDE4A (0.36) | HDAC2HDAC8HDAC6LRRK2MAPK14 | |
| SCHEMBL20436631 | 0.87 | ADORA2A (0.40) | HDAC2HDAC8HDAC6MAPK14ADORA2A | |
| SCHEMBL20436555 | 0.87 | ADORA2A (0.46) | LRRK2ADORA2AADORA2BADORA1 | |
| SCHEMBL20416673 | 0.86 | CNR1 (0.38) | HDAC2HDAC8HDAC6LRRK2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ARCUS BIOSCIENCES, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215730-A1 | AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS | ADORA2A, ADORA2B, ADORA1 | HDAC2 2394/4885HDAC8 1885/4885HDAC6 3173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.