Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.67 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.67 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359122 | 0.98 | CRBN (0.64) | CRBNFKBP5OR51E2KDM4EGAA | |
| N-Methyl Pyrrolidine (Nmp) SCHEMBL6894131 | 0.94 | OR51E2 (0.65) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL21452824 | 0.92 | CRBN (0.54) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL20602673 | 0.82 | CRBN (0.59) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL30123221 | 0.82 | — | — | |
| SCHEMBL4299448 | 0.82 | — | — | |
| SCHEMBL5542 | 0.82 | — | — | |
| SCHEMBL5899535 | 0.81 | CRBN (0.57) | CRBNFKBP5OR51E2KDM4EGAA | |
| Caprolactam SCHEMBL28174316 | 0.80 | CRBN (0.84) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL25430542 | 0.79 | CRBN (0.94) | CRBNFKBP5OR51E2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136887-A1 | COMPOUNDS | TESARO, INC. (US) | 2018-07-26 | — | — | WO | disclosed |