Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 9/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16660965 | 0.84 | DGAT1 (0.41) | DGAT1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16661210 | 0.83 | DGAT1 (0.38) | DGAT1MAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL16660837 | 0.80 | DGAT1 (0.46) | DGAT1HDAC1HDAC6HDAC5 | |
| SCHEMBL16660946 | 0.79 | DGAT1 (0.39) | DGAT1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16660989 | 0.79 | DGAT1 (0.42) | DGAT1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16660962 | 0.78 | DGAT1 (0.42) | DGAT1MAPTMEN1KMT2A | |
| SCHEMBL16661294 | 0.76 | DGAT1 (0.51) | DGAT1 | |
| SCHEMBL15438253 | 0.72 | DGAT1 (0.37) | DGAT1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL16660943 | 0.72 | DGAT1 (0.49) | DGAT1HDAC1HDAC6HDAC5MEN1 | |
| SCHEMBL16661211 | 0.72 | DGAT1 (0.40) | DGAT1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862856-B1 | IMIDAZOLE AND TRIAZOLE COMPOUNDS AS DGAT-1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-08-01 | — | — | EP | disclosed |