Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16660820 | 0.85 | DGAT1 (0.62) | DGAT1 | |
| SCHEMBL16660809 | 0.77 | DGAT1 (0.61) | DGAT1 | |
| SCHEMBL9940365 | 0.66 | DGAT1 (1.00) | DGAT1 | |
| SCHEMBL16660885 | 0.65 | DGAT1 (0.67) | DGAT1 | |
| SCHEMBL15293764 | 0.64 | DGAT1 (0.57) | DGAT1 | |
| SCHEMBL16661023 | 0.64 | DGAT1 (0.59) | DGAT1 | |
| SCHEMBL16661080 | 0.62 | DGAT1 (0.62) | DGAT1 | |
| SCHEMBL16660907 | 0.62 | DGAT1 (0.60) | DGAT1 | |
| SCHEMBL16660817 | 0.62 | DGAT1 (0.69) | DGAT1 | |
| SCHEMBL3881117 | 0.60 | DGAT1 (0.49) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862856-B1 | IMIDAZOLE AND TRIAZOLE COMPOUNDS AS DGAT-1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-08-01 | — | — | EP | disclosed |