Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15204826 | 0.82 | KMT2A (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL162901 | 0.82 | KMT2A (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL17711400 | 0.78 | GRM5 (0.47) | GRM5 | |
| SCHEMBL15811833 | 0.78 | GRM5 (0.47) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15838913 | 0.78 | GRM5 (0.47) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15811834 | 0.78 | GRM5 (0.47) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL231752 | 0.78 | GRM5 (0.53) | GRM5NPC1ALDH1A1GAALMNA | |
| SCHEMBL1476030 | 0.78 | GRM5 (0.55) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20429001 | 0.77 | GAA (0.40) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL20428982 | 0.77 | KMT2A (0.40) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354651-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica N.V. (BE) | 2018-08-01 | — | — | EP | disclosed |