Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27370019 | 0.89 | SYK (0.46) | SYKPCSK9AAK1GAAL3MBTL1 | |
| SCHEMBL30669312 | 0.87 | CXCR1 (0.46) | SYKADRB3ATM | |
| SCHEMBL12817338 | 0.85 | ACHE (0.44) | SYKPPARGPPARAPCSK9AAK1 | |
| SCHEMBL31724476 | 0.84 | SYK (0.43) | SYKPPARGPPARAADRB2ADRB1 | |
| SCHEMBL12987710 | 0.84 | SYK (0.43) | SYKPPARGPPARAADRB2ADRB1 | |
| SCHEMBL2552301 | 0.84 | AAK1 (0.50) | SYKPCSK9AAK1SERPINE1CTSS | |
| SCHEMBL255676 | 0.84 | AAK1 (0.50) | SYKPCSK9AAK1SERPINE1CTSS | |
| SCHEMBL165863 | 0.84 | SYK (0.41) | SYKPCSK9AAK1TDP1GAA | |
| SCHEMBL5877530 | 0.84 | AAK1 (0.50) | SYKPCSK9AAK1SERPINE1CTSS | |
| SCHEMBL27372046 | 0.84 | ACACB (0.44) | SYKADRB2ADRB1PCSK9TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354643-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2018-08-01 | — | — | EP | disclosed |