Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.49 |
| ▸ | PDE4A | P27815 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18872625 | 1.00 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DTACR3 | |
| SCHEMBL18872920 | 0.91 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DTACR3 | |
| SCHEMBL20429656 | 0.91 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DTACR3 | |
| SCHEMBL18671554 | 0.91 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DTACR3 | |
| SCHEMBL20429667 | 0.91 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL18872902 | 0.91 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL18671555 | 0.90 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DTACR3 | |
| SCHEMBL22152168 | 0.89 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL20429759 | 0.86 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DTACR3 | |
| SCHEMBL20429692 | 0.84 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189044-B1 | CRYSTALLINE (2S)-3-[(3S,4S)-3-[(1R)-1-HYDROXYETHYL]-4-(4-METHOXY-3-{[1-(5-METHYLPYRIDIN-2-YL)AZETIDIN-3-YL]OXY}PHENYL) -3-METHYLPYRROLIDIN-1-YL]-3-OXOPROPANE-1,2-DIOL | LILLY CO ELI (US) | 2018-08-01 | — | — | EP | disclosed |