Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2039118 | 0.83 | IKBKE (0.41) | LRRK2TBK1MAPK13MAPK12MAPK11 | |
| SCHEMBL2041982 | 0.82 | DYRK1A (0.38) | LMNAKDM4EACVR1 | |
| SCHEMBL2039350 | 0.77 | FYN (0.41) | LRRK2MEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2044495 | 0.74 | FYN (0.43) | LRRK2ADORA2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL2042257 | 0.71 | KMT2A (0.43) | LRRK2MEN1KMT2AKDM4E | |
| SCHEMBL2048448 | 0.71 | SMN1; SMN2 (0.46) | LRRK2KDRMEN1CYP1A2CYP3A4 | |
| SCHEMBL2043476 | 0.71 | CYP11B2 (0.41) | LMNACYP1A2CYP3A4CYP2D6KDM4E | |
| SCHEMBL2044964 | 0.70 | FYN (0.42) | LRRK2KMT2AKDM4ECDK9 | |
| SCHEMBL2044489 | 0.70 | LRRK2 (0.51) | LRRK2CDK1KDRLMNACYP1A2 | |
| SCHEMBL2048440 | 0.70 | PIM1 (0.41) | LRRK2TBK1CHUKMAPK8CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075613-A1 | AZAINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2011-06-23 | — | — | WO | claimed |
| WO-2011075613-A1 | AZAINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2011-06-23 | — | — | WO | disclosed |