Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 12/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17078474 | 1.00 | HDAC1 (0.59) | HDAC1HDAC6HDAC4KCNH2HDAC8 | |
| SCHEMBL17078470 | 0.90 | FAAH (0.50) | HDAC1HDAC6FAAHGRIN2B | |
| SCHEMBL17078700 | 0.88 | HDAC1 (0.57) | HDAC1HDAC6FAAHGRIN2B | |
| SCHEMBL20432784 | 0.88 | HDAC1 (0.68) | HDAC1HDAC6HDAC8FAAHGRIN2B | |
| SCHEMBL17079056 | 0.88 | HDAC1 (0.68) | HDAC1HDAC6HDAC8FAAHGRIN2B | |
| SCHEMBL20432713 | 0.88 | HDAC1 (0.57) | HDAC1HDAC6FAAHGRIN2B | |
| SCHEMBL17078858 | 0.87 | HDAC6 (0.54) | HDAC1HDAC6HDAC4HDAC8HDAC2 | |
| SCHEMBL17078965 | 0.86 | GRIN2B (0.57) | FAAHGRIN2BNAMPT | |
| SCHEMBL17078569 | 0.86 | HDAC1 (0.53) | HDAC1HDAC6HDAC4KCNH2HDAC8 | |
| SCHEMBL20432848 | 0.86 | HDAC1 (0.54) | HDAC1HDAC6FAAHGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116859-B1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-08-01 | — | — | EP | disclosed |