Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20432768 | 0.89 | HDAC1 (0.70) | HDAC1HDAC6HDAC4KCNH2HIF1A | |
| SCHEMBL17086811 | 0.86 | HDAC1 (0.56) | HDAC1HDAC6HDAC4KCNH2HIF1A | |
| SCHEMBL17079047 | 0.86 | HDAC1 (1.00) | HDAC1HDAC6HDAC4KCNH2HDAC8 | |
| SCHEMBL20432723 | 0.85 | HDAC1 (0.55) | HDAC1HDAC6HDAC4KCNH2HIF1A | |
| SCHEMBL17086812 | 0.85 | HDAC1 (0.56) | HDAC1HDAC6HDAC4KCNH2HIF1A | |
| SCHEMBL17086805 | 0.85 | HDAC1 (0.68) | HDAC1HDAC6HDAC4KCNH2HDAC8 | |
| SCHEMBL17086721 | 0.83 | HDAC1 (0.53) | HDAC1HDAC6HDAC4KCNH2HIF1A | |
| SCHEMBL17086723 | 0.83 | HDAC1 (0.53) | HDAC1HDAC6HDAC4KCNH2HIF1A | |
| SCHEMBL20432705 | 0.82 | HDAC1 (0.57) | HDAC1HDAC6KDM4E | |
| SCHEMBL20432707 | 0.82 | HDAC1 (0.57) | HDAC1HDAC6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116859-B1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-08-01 | — | — | EP | disclosed |