Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 6/20 | 0.55 |
| ▸ | CA2 | P00918 | 6/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325239 | 1.00 | MAPT (0.60) | MAPTLMNAROS1CDK5ACVR1 | |
| SCHEMBL6325243 | 1.00 | MAPT (0.60) | MAPTLMNAROS1CDK5ACVR1 | |
| SCHEMBL20436333 | 0.83 | CA1 (0.62) | MAPTLMNAROS1CDK5ACVR1 | |
| SCHEMBL5739473 | 0.83 | CA1 (0.62) | MAPTLMNAROS1CDK5ACVR1 | |
| SCHEMBL30813240 | 0.79 | LRRK2 (0.60) | LRRK2CA1CA2AGTR1CA9 | |
| SCHEMBL6322987 | 0.79 | TGM2 (0.61) | MAPTLRRK2CA1CA2AGTR1 | |
| SCHEMBL7220775 | 0.79 | SMN1; SMN2 (0.40) | MAPTLMNALRRK2CA1CA2 | |
| SCHEMBL6315587 | 0.79 | TGM2 (0.61) | MAPTLRRK2CA1CA2AGTR1 | |
| SCHEMBL16168103 | 0.79 | MAP3K7 (0.46) | MAPTLMNAROS1CDK5ACVR1 | |
| SCHEMBL23612445 | 0.79 | HPGD (0.46) | MAPTLMNALRRK2AGTR1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573960-B1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2023-08-16 | — | — | EP | disclosed |
| WO-2018138362-A1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |