Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19177266 | 0.80 | KDM4E (0.46) | KDM4EMAPTHSD17B10HIF1ADUSP3 | |
| SCHEMBL3439599 | 0.76 | MAPT (0.57) | KDM4EMAPTHSD17B10HIF1ADUSP3 | |
| SCHEMBL21895251 | 0.73 | KDM4E (0.48) | KDM4EMAPTHSD17B10HIF1ADUSP3 | |
| SCHEMBL21577671 | 0.71 | MAPT (0.36) | KDM4EMAPTHSD17B10HIF1AALDH1A1 | |
| SCHEMBL3368788 | 0.71 | TAAR1 (0.64) | MAPTHIF1AALDH1A1KMT2ATAAR1 | |
| SCHEMBL24702447 | 0.67 | TAAR1 (0.45) | HIF1AALDH1A1TAAR1 | |
| SCHEMBL21755768 | 0.65 | TAAR1 (0.56) | HIF1AALDH1A1TAAR1 | |
| SCHEMBL12775851 | 0.65 | KDM4E (0.47) | KDM4EMAPTHSD17B10HIF1ADUSP3 | |
| SCHEMBL19670976 | 0.64 | TAAR1 (0.50) | HIF1AALDH1A1TAAR1 | |
| SCHEMBL13401708 | 0.64 | ALDH1A1 (0.52) | KDM4EMAPTHSD17B10HIF1ADUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MKI67, MCL1 | KDM4E 1555/4885MAPT 4535/4885HSD17B10 1954/4885 |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | DCX, MKI67, MCL1 | KDM4E 1555/4885MAPT 4535/4885HSD17B10 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.