Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | DTYMK | P23919 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29839987 | 0.84 | MTNR1A (0.42) | MTNR1AMTNR1BKDM4ECYP1A2MAPT | |
| SCHEMBL20594981 | 0.84 | MTNR1A (0.42) | MTNR1AMTNR1BKDM4ECYP1A2MAPT | |
| SCHEMBL20565261 | 0.82 | POLB (0.47) | MTNR1AMTNR1BKDM4ECYP1A2MAPT | |
| SCHEMBL9847025 | 0.82 | MTNR1A (0.44) | MTNR1AMTNR1BKDM4ECYP1A2MAPT | |
| SCHEMBL27530925 | 0.82 | MTNR1A (0.40) | MTNR1AMTNR1BKDM4ECYP1A2MAPT | |
| SCHEMBL16940012 | 0.82 | MTNR1A (0.40) | MTNR1AMTNR1BKDM4ECYP1A2MAPT | |
| SCHEMBL24758783 | 0.81 | MTNR1A (0.40) | MTNR1AMTNR1BKDM4ECYP1A2MAPT | |
| SCHEMBL9863289 | 0.78 | MTNR1A (0.52) | MTNR1AMTNR1BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL21437438 | 0.77 | CHRM2 (0.50) | MTNR1AMTNR1BKDM4EMAPTALDH1A1 | |
| SCHEMBL19841327 | 0.75 | MTNR1A (0.36) | MTNR1AMTNR1BKDM4ECYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180216107-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2018-08-02 | — | — | US | disclosed |