Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.34 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2043943 | 0.98 | HDAC8 (0.54) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| Bromide SCHEMBL153043 | 0.98 | HDAC8 (0.54) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| Bromide SCHEMBL2043946 | 0.98 | HDAC8 (0.54) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL688667 | 0.96 | HDAC8 (0.56) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL1292850 | 0.93 | HDAC8 (0.54) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| Iodide SCHEMBL11354908 | 0.93 | HDAC8 (0.54) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL16632906 | 0.83 | ACHE (0.45) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| Bromide SCHEMBL4622171 | 0.83 | HDAC8 (0.52) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL20847841 | 0.80 | HDAC8 (0.54) | HDAC8ALDH1A1MEN1KMT2ANPC1 | |
| Bromide SCHEMBL1674572 | 0.79 | HTT (0.53) | HDAC8MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160282-A1 | NUCLEIC-ACID PHARMACEUTICAL COMPOSITION FOR CANCER THERAPY | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2011-06-30 | — | — | US | claimed |
| US-7745419-B2 | Pharmaceutical composition for treating cancer | KOREA UNIVERSITY INDUSTRIAL & ACADEMIC COLLABORATION FOUNDATION (KR) | 2010-06-29 | — | — | US | claimed |
| WO-2009104896-A2 | NUCLEIC-ACID PHARMACEUTICAL COMPOSITION FOR CANCER THERAPY | 고려대학교 산학협력단 (KR) | 2009-08-27 | — | — | WO | claimed |
| US-20090081282-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER | KOREA UNIVERSITY INDUSTRIAL & ACADEMIC COLLABORATION FOUNDATION (KR) | 2009-03-26 | — | — | US | claimed |
| US-20110160282-A1 | NUCLEIC-ACID PHARMACEUTICAL COMPOSITION FOR CANCER THERAPY | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2011-06-30 | — | — | US | disclosed |
| US-7745419-B2 | Pharmaceutical composition for treating cancer | KOREA UNIVERSITY INDUSTRIAL & ACADEMIC COLLABORATION FOUNDATION (KR) | 2010-06-29 | — | — | US | disclosed |
| WO-2009104896-A2 | NUCLEIC-ACID PHARMACEUTICAL COMPOSITION FOR CANCER THERAPY | 고려대학교 산학협력단 (KR) | 2009-08-27 | — | — | WO | disclosed |
| US-20090081282-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER | KOREA UNIVERSITY INDUSTRIAL & ACADEMIC COLLABORATION FOUNDATION (KR) | 2009-03-26 | — | — | US | disclosed |