Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.36 |
| ▸ | CTSS | P25774 | 5/20 | 0.35 |
| ▸ | CTSK | P43235 | 5/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CCKAR | P32238 | 2/20 | 0.34 |
| ▸ | CCKBR | P32239 | 2/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23072645 | 0.89 | HDAC8 (0.42) | HDAC8NTRK1PTPN1CTSSCTSK | |
| SCHEMBL20437159 | 0.87 | HDAC8 (0.42) | HDAC8NTRK1PTPN1CTSSCTSK | |
| SCHEMBL20437165 | 0.87 | HDAC8 (0.42) | HDAC8NTRK1PTPN1CTSSCTSK | |
| SCHEMBL23505694 | 0.82 | MET (0.32) | — | |
| SCHEMBL20437163 | 0.80 | MEN1 (0.44) | HDAC8NTRK1PTPN1CTSSCTSK | |
| SCHEMBL20422614 | 0.79 | MET (0.38) | — | |
| SCHEMBL20422613 | 0.79 | MET (0.38) | — | |
| SCHEMBL20437153 | 0.77 | MEN1 (0.42) | PTPN1CTSSCTSK | |
| SCHEMBL20437151 | 0.76 | MEN1 (0.37) | PTPN1CTSSCTSK | |
| SCHEMBL20437164 | 0.74 | KLK7 (0.39) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3573987-B1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-03-10 | — | — | EP | disclosed |
| WO-2018138293-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | WO | disclosed |