Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.53 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 13/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 8/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28548296 | 0.85 | GRM2 (0.38) | GRM2SLC9A1NFE2L2KEAP1 | |
| SCHEMBL29442748 | 0.82 | GRM2 (0.63) | GRM2SLC9A1HCAR3 | |
| SCHEMBL16831208 | 0.82 | GRM2 (0.63) | GRM2SLC9A1HCAR3 | |
| SCHEMBL20425557 | 0.80 | GRM2 (0.47) | GRM2SLC9A1HCAR3NFE2L2KEAP1 | |
| SCHEMBL29982736 | 0.80 | GRM2 (0.47) | GRM2SLC9A1HCAR3NFE2L2KEAP1 | |
| SCHEMBL20269082 | 0.78 | GRM2 (0.46) | GRM2SLC9A1HCAR3NFE2L2KEAP1 | |
| SCHEMBL17828279 | 0.78 | GRM2 (0.67) | GRM2SLC9A1 | |
| SCHEMBL22084730 | 0.75 | KEAP1 (0.41) | SLC9A1HCAR3NFE2L2KEAP1POLB | |
| SCHEMBL18323587 | 0.73 | GRM2 (0.43) | GRM2SLC9A1HCAR3POLB | |
| SCHEMBL22084732 | 0.73 | KDM4E (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140876-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-08-02 | — | — | WO | disclosed |