Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | POR | P16435 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26289050 | 0.77 | PTPN1 (0.30) | — | |
| SCHEMBL20440241 | 0.74 | ALDH2 (0.36) | ALDH2MAOAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL20440249 | 0.74 | ALDH2 (0.36) | ALDH2ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL20440243 | 0.73 | ALDH1A1 (0.36) | ALDH2MAOAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL20440251 | 0.72 | ALDH2 (0.34) | ALDH2ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL20439852 | 0.70 | ALDH1A1 (0.37) | ALDH2ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL20439841 | 0.68 | PRKDC (0.47) | — | |
| SCHEMBL20440242 | 0.68 | ALDH1A1 (0.35) | ALDH2ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL20439851 | 0.68 | PRKDC (0.60) | ALDH1A1KDM4EHSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL20439806 | 0.67 | KDM4E (0.35) | ALDH2ALDH1A1KDM4EHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140730-A1 | THIENOPYRANONES AND FURANOPYRANONES AS KINASE, BROMODOMAIN, AND CHECKPOINT INHIBITORS | SIGNALRX PHARMACEUTICALS, INC. (US) | 2018-08-02 | — | — | WO | disclosed |